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World's First Triple-Helix Biomimetic Collagen ECM Regenerative Material

The third generation of biomimetic collagen after animal-extracted and recombinant collagen

Three Generations of Collagen Preparation

World's first triple-helix biomimetic collagen ECM

Animal Extraction

Risk of viral transmission and immunogenicity; poor solubility; hard to modify specifically; has a triple-helix structure

Genetic Recombination

Scalable manufacturing; proline is hard to hydroxylate site-specifically, lacking hydroxyproline; usually no triple-helix structure

Biomimetic Synthesis

Latest-generation collagen; biomimetic, non-immunogenic, easy to handle and functionalize; stable triple-helix structure

Materials Science

POGMENT Triple-Helix Biomimetic Collagen ECM

Amino Acid Model Schematic

Amino acid sequences precisely recreate the native collagen Gly-X-Y repeat. 300 kV cryo-EM confirms stable self-assembled fiber bundles—from a single peptide chain to nanoscale fiber networks, from aqueous polymerization to self-crosslinking gels. LivingPHOENIX has ended both the risks of animal extraction and the structural gaps of recombinant collagen.

Animal-free. Virus-free. Non-immunogenic. Survives 121°C moist-heat terminal sterilization. Epithelialization up to 12× bovine collagen and 8.13× recombinant collagen.

This is not an upgrade of recombinant collagen—it is collagen coming home. Regeneration starts with the right structure.

Scientific Validation of the Triple-Helix Structure

First high-resolution fiber-bundle imaging of biomimetic collagen worldwide

TITAN KRIOS G4 Cryo-EM

Using the 300 kV cryo-TEM TITAN KRIOS G4, we captured the self-assembled collagen morphology of multiple POGMENT biomimetic collagen batches.

Cryo-EM imaging of triple-helix structure

Biomimetic collagen promotes collagen deposition significantly better than recombinant collagen

Biomimetic collagen promotes collagen deposition significantly better than marketed recombinant collagen lyophilized fibers

Proteomics-based mapping of the ECM regulatory network enables multi-target anti-inflammatory repair and tissue regeneration

Application Fields

Built on triple-helix biomimetic collagen, five material platforms—liquid, self-crosslinked, co-crosslinked, smart gelation, and biomimetic composites—serve medical devices, cosmetics, and tissue regeneration.

Liquid Triple-Helix Biomimetic Collagen ECM —— Formulation-Friendly —— Supports injection / lyophilized reconstitution, compatible with moist-heat sterilization; suits Class II/III devices and cosmetics.
Self-Crosslinked Triple-Helix Biomimetic Collagen ECM —— In Situ Regenerative Network —— No exogenous crosslinker; porous structure promotes vascular ingrowth for facial contouring and cartilage repair.
Co-Crosslinked Triple-Helix Biomimetic Collagen ECM —— Mechanics & Bioactivity Balance —— Full-spectrum mechanical customization with strong anti-degradation for sports injuries and load-bearing joints.
Smart-Gelation Triple-Helix Biomimetic Collagen ECM —— Minimally Invasive In Situ Forming (R&D) —— Thermo/pH dual response: inject as liquid, gel in situ within <10 min at body temperature for burns, ulcers, and post-aesthetic care.
Biomimetic Composite Triple-Helix Collagen ECM —— Multi-Component Synergy —— Combined with bioceramics / conductive polymers / HA to actively guide bone, nerve, vessel, and corneal regeneration.